Glioblastoma (GBM)

Most aggressive and common malignant brain tumor type

AOverview

Quick and clear information for patients

What is this Condition?

Symptoms

Severe and persistent headaches (more prominent in the morning)
Persistent nausea and vomiting (increased intracranial pressure)
Seizures (epileptic crises) - may be the first symptom
Weakness in arm or leg (hemiparesis)
Speech disorders and word-finding difficulty
Personality changes, memory loss and behavioral disorders

Diagnosis Methods

Diagnosis is made with contrast-enhanced brain MRI - typically showing ring-shaped contrast enhancement and central necrosis. CT evaluates calcification and hemorrhage areas. Definitive diagnosis is made by pathological examination after stereotactic biopsy or surgical resection. Advanced imaging methods (perfusion MRI, MR spectroscopy, PET-CT) can be used to assess tumor grade and metabolic activity.

Treatment Methods

Maximal Safe Surgical Resection
Concurrent Chemoradiotherapy (Stupp Protocol)
Adjuvant Temozolomide Chemotherapy
TTFields (Tumor Treating Fields) Electric Field Therapy

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