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Nerve Biopsy

Tissue sampling from a peripheral nerve for diagnostic purposes

What is This Treatment?

A procedure in which tissue samples are surgically obtained from a peripheral nerve (usually the sural nerve) for diagnosing peripheral neuropathy. It provides critical information for diagnosing vasculitic neuropathy, amyloidosis, sarcoidosis, and inflammatory neuropathies.

Benefits

  • Provides definitive histopathological diagnosis in neuropathy etiology
  • Enables confirmation of vasculitic and inflammatory neuropathies
  • Allows differentiation of myelinopathy and axonopathy with electron microscopy
  • Offers important information for treatment guidance

Treatment Process

Sural nerve biopsy is most commonly performed. Under local anesthesia, the nerve is exposed through a skin incision at the lateral ankle and a segment is excised. The specimen is processed for pathology and electron microscopy.

When is it used?

  • Diagnosis of vasculitic neuropathy
  • Tissue confirmation in suspected amyloid neuropathy
  • Evaluation of chronic inflammatory demyelinating polyneuropathy
  • Diagnosis of unexplained peripheral neuropathies

Recovery and planning

Permanent numbness in the distribution area of the biopsied nerve may occur. Wound care and suture removal after 10-14 days are required.

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The treatment plan is personalized after examination, imaging, and neurological assessment.

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Nerve Biopsy | Dr. Özgür AKŞAN